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{07} {35} {36} Both allopurinol and the uricosuric antigout agents are effective in patients whose 24-hour renal excretion of uric acid is 800 mg (4. Do not use this medication if you are allergic to didanosine, or if you are also taking allopurinol (Zyloprim) or ribavirin (Rebetol, Ribasphere, Copegus Virazole). A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. This pathway of Thioguanine inactivation is not dependent on the action of xanthine oxidase, and an inhibitor of that enzyme (such as allopurinol) will not block the detoxification of Thioguanine even though the inactive 6-thioxanthine is normally further oxidized by xanthine oxidase to thiouric acid before it is eliminated. A reaction with another antigout drug, allopurinol, may cause a rash.
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